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Intramuscular epinephrine is the recommended drug for anaphylactic reactions (SOR A). Renal impairment: glomerular filtration rate (GFR) 10–30mL/min: 250mg or 500mg every 12hrs; GFR <10mL/min or hemodialysis: 250mg or 500mg every 24hrs (give additional dose during and at end of dialysis). I’ve been taking 20-30 mg amitriptyline nightly for 8 years now for ME.
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